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Research / Unapproved

MK-677 (Ibutamoren): Research Status and Trial Data

Molecular formulaC28H40N4O8S2
Molecular weight624.8 g/mol
Registered trials8
PubChem CID6450830

What MK-677 Is

MK-677, also known as Ibutamoren, is a synthetic compound with the molecular formula C28H40N4O8S2 and a molecular weight of about 624.8 g/mol (PubChem CID 6450830). It does not have an approved drug label from any regulatory agency, and it is classified as an unapproved research compound. No FDA-sanctioned indications, dosing standards, or mechanism-of-action statements exist for it in official labeling.

Trial Footprint

Clinicaltrials.gov lists 8 registered trials involving MK-677. Sampled studies include a completed Phase 2 trial examining Ibutamoren's impact on nonalcoholic fatty liver disease (NCT05364684) and a completed Phase 2 trial evaluating an oral growth hormone secretagogue drug for fibromyalgia (NCT00116129). Another completed trial studied the effect of the growth hormone secretagogue MK-0677 on IGF-1 levels in patients with end-stage renal disease (NCT00395291). These entries describe study design and status only, not outcomes or efficacy.

FAQ

Is MK-677 FDA approved?
No. MK-677, also called Ibutamoren, has no FDA-approved label and is classified as an unapproved research compound. There is no official indication, dosing guidance, or mechanism statement from a regulatory body for this substance.
What is MK-677 being studied for?
Registered trials have examined MK-677 in contexts such as nonalcoholic fatty liver disease, fibromyalgia, and IGF-1 levels in patients with end-stage renal disease. These are research studies and do not establish that the compound is safe or effective for any use.
How many clinical trials have involved MK-677?
Clinicaltrials.gov lists 8 registered trials involving this compound as of the most recent data pull. The available sample includes completed Phase 2 studies and one trial without a specified phase.
Is MK-677 the same as Ibutamoren?
Yes, Ibutamoren is another name used for MK-677 in scientific literature and trial registrations, including under the designation MK-0677. Both names refer to the same compound (PubChem CID 6450830).
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Sources: PubChem CID 6450830 ClinicalTrials.gov (NCT05364684, NCT00116129, NCT00395291)

Updated 2026-09-26